How does your antibody compare?

Paste its variable domains. We number them, assign their germline, fold the Fv, and compute what a developability review asks for: solvent exposure and aggregation propensity per residue, surface hydrophobicity and charge, chemical liability motifs graded by exposure, MHC-II presentation across seven DRB1 alleles, and humanness with a proposed humanised variant. Twenty-six molecule-level numbers come with their percentile among 906 clinical-stage antibodies, and everything that can be placed on a residue is. You get a workbook of all of it, on the page and as Excel.

Scientific overview (PDF) - what each number is, the published method behind it, and what it cannot tell you.

Your sequences and your result are deleted after 7 days. They are not shared, and they are used for nothing but your result. Your email address is used to send you the link, and is deleted with your result unless you ask us to write to you. The link we mail you starts the analysis and works for 72 hours. One address may ask for 5 profiles a day, since each one holds a GPU while it folds.

VH, the heavy chain's variable domain VL, the light chain's variable domain - leave empty for a single-domain antibody

The domain alone, without the constant region: about 110 to 130 residues, ending where the J region does.

No sequence to hand? Profile one of these marketed antibodies:

Trastuzumab Adalimumab Bevacizumab

A name for it - optional Your email address

A private link to your report will be sent here, with a link to remove your address. How we handle your data is in our privacy policy.

Also write to me about Bionamic now and then. You can stop it at any time with the link in every mail.