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Research use cases

Examples of research workflows in Bionamic for biotech and biologics teams. We add new use cases in collaboration with customers.

Clone promotion funnel across every assay of a discovery campaign, with the surviving clones drawn through it

Discovery campaign analysis

Integrate a campaign’s assay exports and read the thresholds that promoted clones down the funnel.
Dose-response curves for two responding antibodies against one antigen, plotted in a Bionamic workbook

Dose-response across an antibody panel

Fit fifty titrations from one assay export and keep the ten that describe a real response.
Total-antibody concentration-time curves for individual mice, coloured by antibody and conjugate, in a Bionamic workbook

Pharmacokinetics of an ADC series

Run a non-compartmental analysis of a mouse PK study and see how clearance and payload loss change with drug load.
Simulated concentrations of an antibody and three drug conjugates over four doses every three weeks, with the trough before each dose, in a Bionamic workbook

A PK model of an ADC series

Fit a linked model of total antibody and conjugated ADC, and simulate a dosing schedule before running it.
Antibody molecular surface colored by its properties

Antibody developability profiling

Move from raw sequences to annotated molecules and developability signals in a workbook.
UMAP of antibody structure properties in a Bionamic workbook, with kappa and lambda light chains colored

Sequence and structure mapping

Compare surface properties and use UMAP clustering to explore similarities between antibody candidates.
A knob-into-hole antibody drawn from its four named chains after being read from pasted sequences

Identify an antibody from its sequences

Work out what a set of chain sequences is made of, and which molecule they add up to.
Antibody format diagrams in Bionamic

ELN-ready biomolecules

Build antibody formats, annotate their chains, and validate records before registration.
Antibody registration workflow in a Bionamic workbook

Register antibodies in Revvity Signals

Transfer annotated antibody records from a Bionamic workbook into an electronic lab notebook.