Antibody developability profiling

Move from raw antibody sequences to annotated molecule records and developability predictions in a Bionamic workbook.

Start with a sequence table

Paste sequences from Excel or import them from FASTA files. In this example, VH and VL antibody sequences are added to a workbook table for profiling.

Bionamic workbook table with VH and VL antibody sequences

Build and annotate molecules

Run functions directly from the spreadsheet to build molecules and add sequence annotations such as numbering, PTM motifs, and CDR ranges. Results appear in the same table.

Bionamic workbook showing built VH-VL molecules and sequence annotations

Profile molecules

Extend the table with developability predictions and calculated properties such as immunogenicity, structural solubility, aggregation propensity, and other project-specific risk signals.

Customize the analysis

Annotation rules, liability definitions, prediction tools, and output columns can reflect a combination of project-specific priorities and customer-wide guidelines.