Try it on your own antibody
Free, and with no account. Paste your sequences, and we email you a private link to the result: a workbook you can explore on the page, as the Bionamic app shows it, and download as Excel.
Antibody chain profiler
Paste whole chains and get each one read end to end: the constant region's isotype, allotype and every engineered mutation in it, with what the mutation is for and where it was published; the variable domains' IMGT numbering, CDRs, nearest germline genes and somatic mutations.
Seconds.
OpenAntibody developability profile
Paste the variable domains, VH and VL (or a VHH alone), and get the profile a lead is judged by: the domains folded, aggregation and surface exposure on the structure, sequence liabilities, MHC-II T-cell epitopes, humanness with suggested humanizing mutations, germline and somatic mutations - and where it all sits among 906 clinical-stage antibodies.
A few minutes. It folds the antibody on a GPU.
Open